United StatesBiodefense Solutions
Facts About SmallpoxSmallpox infection was eradicated from the world in 1977. Smallpox is caused by the variola virus. The incubation period is about 12 days (range: 7 to 17 days) following exposure. Initial symptoms include high fever, fatigue, and head and back aches. A characteristic rash, most prominent on the face, arms, and legs, follows in 2-3 days. The rash starts with flat red lesions that evolve at the same rate. Lesions become pus-filled and begin to crust early in the second week. Scabs develop and then separate and fall off after about 3-4 weeks. The majority of patients with smallpox recover, but death occurs in up to 30% of cases. Smallpox is spread from one person to another by infected saliva droplets that expose a susceptible person having face-to-face contact will the ill person. Persons with smallpox are most infectious during the first week of illness, because that is when the largest amount of virus is present in saliva. However, some risk of transmission lasts until all scabs have fallen off. In people exposed to smallpox, the vaccine can lessen the severity of or even prevent illness if given within a few days after exposure. Vaccine against smallpox contains another live virus called vaccinia. The vaccine does not contain the smallpox virus. There is no proven treatment for smallpox but research to evaluate new antiviral agents is ongoing. Patients with smallpox can benefit from supportive therapy (intravenous fluids, medicine to control fever or pain, etc.) and antibiotics for any secondary bacterial infections that may occur. References:
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