BD Discovery Platform



Cell Surface Protein Characterization

BD has leveraged its large and diverse catalog of high quality antibodies to develop
BD FACS™ CAP (Combinational Antibody Profile). BD FACS™ CAP is a proteomic cell characterization tool developed to identify and analyze cell surface proteins expressed on a specific cell type.  The result is an inventory of receptors and markers present on the cell, yielding an information-rich ‘fingerprint’ that can be used to:

  • Analyze extracellular matrix and soluble factors that influence cell growth or differentiation
  • Analyze donor to donor and passage to passage variability in clinical samples
  • Discover cell type specific biomarkers
  • Develop QC assays

BD FACS™ CAP is supported by a proprietay software analysis package that will display the results for customers in both spreadsheet and graphical (heat map) format. Once a subset of antibody targets of interest is identified using BD FACS™ CAP, a focused subset of antibodies - BD FACS™ CAP Select – can be provided as a custom product for the customer’s on-going characterization,  selection and isolation of the desired cell type.

BD FACS™ CAP is available as a  stand-alone custom service for cell characterization and analysis. It is also the recommended first step in the Discovery Platform process.

Please view and download the BD FACS™ CAP Data Sheet.

Graphical representation of BD FACS™ CAP screen showing relative expression of cell surface markers on multiple cell types from multiple donors. Color key represents percent positive cells.

 

      BD FACS™ CAP

  • 212 fluorescently-labeled anti-human antibodies

  • Multiplexed in 96-well plate format

  • Analysis supported by proprietary software

  • Provides an inventory of receptors and markers present on the cell, yielding an information-rich 'fingerprint'