Leading the way in effective pre-op skin prep and setting the standard of care in surgical infection prevention
ChloraPrep is the first antiseptic with a 2% chlorhexidine gluconate (CHG) / 70% isopropyl alcohol (IPA) formulation and provides distinct advantages over other products in how to prepare for surgery.
Below you can see the various traits of common antimicrobial agents used today.
ChloraPrep FAQs »
| Active agents |
Traditional iodophors |
Alcohol |
Chlorhexidine* |
| Broad spectrum |
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| Rapid bactericidal activity |
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| Residual activity |
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| Activity in blood/organic matter |
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| Non/Minimal absorption |
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The ChloraPrep formulation uses a combination of chlorhexidine and isopropyl alcohol to provide both rapid killing of bacteria and persistent antimicrobial activity.
IPA rapidly kills microorganisms by denaturing cell proteins, while CHG maintains persistent antimicrobial activity by disrupting the cell membrane and precipitating cell contents. Additionally, CHG is able to bind to the skin and retain antimicrobial activity in the presence of blood and other organic material.
The unique dual formulation offered by ChloraPrep skin preparation has been shown to outperform iodine-based products. 1,2,3
Proven Formulation
ChloraPrep is the only formulation whose persistent antimicrobial power was confirmed in study after clinical study. With a well-documented history in clinical practice, ChloraPrep skin preparation appears in Level I evidence-based studies. In fact, the unique 2% CHG and 70% IPA ChloraPrep formulation appears in more than 50 peer-reviewed publications.
“… because the efficacy of any formulation is significantly affected by the excipients present, trials demonstrating activity of one formulation can not be used as evidence for the efficacy of another.”
- Graham W. Denton
Denton G. Chlorhexdine. In: Block S, ed. Disinfection, Sterilisation and Preservation. 5th ed. Lippincott Williams and Wilkins. 2001
The recommendations are clear
ChloraPrep meets third party evidence-based standards for preoperative skin antisepsis according to leading healthcare organizations. 4,5,6
| Year |
Organization |
Study |
| 2016 |
World Health Organization (WHO) 4 |
The panel recommends alcohol-based antiseptic solutions based on CHG for surgical skin site preparation. |
| 2016 |
American College of Surgeons and Surgical Infection Society 5 |
Alcohol-containing preoperative skin preparatory agents should be used unless contraindication exists. |
| 2017 |
Centers for Disease Control and Prevention (CDC) 6 |
Perform intraoperative skin preparation with an alcohol-based antiseptic agent unless contraindicated. |
