The formulation

Leading the way in effective pre-op skin prep and setting the standard of care in surgical infection prevention

ChloraPrep is the first antiseptic with a 2% chlorhexidine gluconate (CHG) / 70% isopropyl alcohol (IPA) formulation and provides distinct advantages over other products in how to prepare for surgery.

Below you can see the various traits of common antimicrobial agents used today.

ChloraPrep FAQs »

Comparison of antimicrobial agents
Active agents Traditional iodophors Alcohol Chlorhexidine*
Broad spectrum
Rapid bactericidal activity    
Residual activity    
Activity in blood/organic matter    
Non/Minimal absorption    

The ChloraPrep formulation uses a combination of chlorhexidine and isopropyl alcohol to provide both rapid killing of bacteria and persistent antimicrobial activity.

IPA rapidly kills microorganisms by denaturing cell proteins, while CHG maintains persistent antimicrobial activity by disrupting the cell membrane and precipitating cell contents. Additionally, CHG is able to bind to the skin and retain antimicrobial activity in the presence of blood and other organic material.

The unique dual formulation offered by ChloraPrep skin preparation has been shown to outperform iodine-based products. 1,2,3

Proven Formulation

ChloraPrep is the only formulation whose persistent antimicrobial power was confirmed in study after clinical study. With a well-documented history in clinical practice, ChloraPrep skin preparation appears in Level I evidence-based studies. In fact, the unique 2% CHG and 70% IPA ChloraPrep formulation appears in more than 50 peer-reviewed publications.

“… because the efficacy of any formulation is significantly affected by the excipients present, trials demonstrating activity of one formulation can not be used as evidence for the efficacy of another.”

- Graham W. Denton
Denton G. Chlorhexdine. In: Block S, ed. Disinfection, Sterilisation and Preservation. 5th ed. Lippincott Williams and Wilkins. 2001

The recommendations are clear

ChloraPrep meets third party evidence-based standards for preoperative skin antisepsis according to leading healthcare organizations. 4,5,6

Year Organization Study
2016 World Health Organization (WHO) 4 The panel recommends alcohol-based antiseptic solutions based on CHG for surgical skin site preparation.
2016 American College of Surgeons and Surgical Infection Society 5 Alcohol-containing preoperative skin preparatory agents should be used unless contraindication exists.
2017 Centers for Disease Control and Prevention (CDC) 6 Perform intraoperative skin preparation with an alcohol-based antiseptic agent unless contraindicated.


* ChloraPrep patient preoperative skin preparation active agents

  1. Saltzman, M., Nuber, G., Gryzlo, S., Marecek, G. et. al. Efficacy of surgical preparation solutions in shoulder surgery. J Bone Joint Surg Am, 2009, 91(8):1949–1953.
  2. Adler, M., Brigger, K., Bishop, K., Mastrobattista, J. Comparison of bactericidal properties of alcohol-based chlorhexidine versus povidone-iodine prior to amniocentesis. Am J Perinatol, June 2012, 29(6):455–458.
  3. Ostrander, R., Bott, M., Brage, M. Efficacy of surgical preparation solutions in foot and ankle surgery. J Bone Joint Surg Am, 2005, 87(5):980–985.
  4. World Health Organization. Global guidelines for the prevention of surgical site infection. Geneva, Switzerland. 2016
  5. Ban K, Minel J, Laronga C. et al. American College of Surgeons and Surgical Infection Society: Surgical Site Infection Guidelines, 2016 Update J Am Coll Surg. 2017:
  6. Centers for Disease Control and Prevention. Guideline for the prevention of surgical site infection. JAMA Surg. 2017: E1-E8