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Peripheral Arterial Disease

People say they are Vascular Surgeons, Interventional Radiologists or Angiologists. But for us they are Life Openers.

Life Openers
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Peripheral Arterial Disease (PAD) treatment has moved on. Have you?

Across the world, leading vascular teams are rethinking how they approach PAD.

For years, Plain Old Balloon Angioplasty (POBA) alone was the default choice. But today, the data shows that this mindset leads to more problems than you think. That’s why Life Openers are moving forward- and why it’s time to rethink your PAD strategy. 

Why POBA-alone falls short 

Evidence

POBA-alone leads to structural vessel damage and long term risks

POBA-alone may look simple on the surface but the data tells a different story. Dissections, bailout stenting and restenosis add hidden risks that compromise both patient outcomes and procedural inefficiency

Discover the Life Openers story 

  • 84%
    Vessel dissection

    up to 84% of POBA alone cases cause vessel dissection1

  • ~3x
    Bailout stenting

    POBA-alone leads to nearly 3x more bailout stenting 2

  • 50%

    Restenosis

    POBA-alone treatments have around 50% higher rates of restenosis 3

Life Openers Story

The story of Lucien and Mark

 

When Lucien first met Consultant Vascular Surgeon Dr. Mark Portou, he was facing major amputation. Standard treatments were no longer enough. With a modern PAD strategy, Mark and his team saved Lucien’s leg.
 
But something else happened too. Along the way, Lucien and Mark built a bond that went beyond the operating room. Their story is about more than PAD- it’s a story about life, and about opening it up again. 

“PAD is moving fast, and it’s not easy to always stay ahead. But good enough isn’t what got us here”.

- Dr. Mark Portou Consultant Vascular Surgeon practicing in London

Why leading teams are adopting modern vessel preparation
  • Fewer acute failures.

    Modern vessel preparation may reduce the risk of
    acute technical failure by up to 78% 5

  • Less need for bailout stenting.

    Modern vessel preparation may reduce
    bailout stenting rates by up to 85% 5

  • Higher freedom from reintervention.

    Modern vessel preparation might deliver 21% higher freedom from Reintervention 6

  • Lower follow-up costs.

    ~29% lower target limb-related follow-up costs for DCB – due to reduction in repeat revascularisation procedures7

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References
  1. Fujihara M, Takahara M, Sasaki S, et al. Angiographic Dissection Patterns and Patency Outcomes After Balloon Angioplasty for Superficial Femoral Artery Disease. J Endovasc Ther. 2017;24(3):367-375. doi:10.1177/1526602817698634
  2. Jaff MR, Rosenfield K, Scheinert D, et al. Drug-coated balloons to improve femoropopliteal artery patency: Rationale and design of the LEVANT 2 trial. Am Heart J. 2015;169(4):479-485. doi:10.1016/j.ahj.2014.11.016
  3. Krankenberg H, Tübler T, Ingwersen M, et al. Drug-Coated Balloon Versus Standard Balloon for Superficial Femoral Artery In-Stent Restenosis: The Randomized Femoral Artery In-Stent Restenosis (FAIR) Trial. Circulation. 2015;132(23):2230-2236. doi:10.1161/CIRCULATIONAHA.115.017364
  4. Feldman DN, Armstrong EJ, Aronow HD, et al. SCAI consensus guidelines for device selection in femoral-popliteal arterial interventions. Catheter Cardiovasc Interv. 2018;92(1):124-140. doi:10.1002/ccd.27635
  5. Wu Z, Huang Q, Pu H, et al. Atherectomy Combined with Balloon Angioplasty versus Balloon Angioplasty Alone for de Novo Femoropopliteal Arterial Diseases: A Systematic Review and Meta-analysis of Randomised Controlled Trials. Eur J Vasc Endovasc Surg. 2021;62(1):65-73. doi:10.1016/j.ejvs.2021.02.012
  6. Fan W, Lu S, Tan J, et al. Midterm Results of Drug-Coated Balloon Alone or Combined with Rotarex Thrombectomy Device for Treatment of Subacute Femoropopliteal Artery Thrombotic Occlusion. Ann Vasc Surg. 2023;92:240-248. doi:10.1016/j.avsg.2022.11.019
  7. Salisbury AC, Li H, Vilain KR, et al. Cost-Effectiveness of Endovascular Femoropopliteal Intervention Using Drug-Coated Balloons Versus Standard Percutaneous Transluminal Angioplasty: Results From the IN.PACT SFA II Trial. JACC Cardiovasc Interv. 2016;9(22):2343-2352. doi:10.1016/j.jcin.2016.08.036
  8. Pan T, Tian SY, Liu Z, Zhang T, Li C, Ji DH. Combination of Rotarex S Rotational Atherothrombectomy and Drug-Coated Balloonangioplasty for Femoropopliteal Total In-Stent Occlusion. Ann Vasc Surg. 2022;80:213-222. doi:10.1016/j.avsg.2021.08.058
  9. Bailey SR, Beckman JA, Dao TD, et al. ACC/AHA/SCAI/SIR/SVM 2018 Appropriate Use Criteria for Peripheral Artery Intervention: A Report of the American College of Cardiology Appropriate Use Criteria Task Force, American Heart Association, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, and Society for Vascular Medicine. J Am Coll Cardiol. 2019;73(2):214-237. doi:10.1016/j.jacc.2018.10.002
  10. Scheinert D, Schmidt A, Zeller T, et al. German Center Subanalysis of the LEVANT 2 Global Randomized Study of the Lutonix Drug-Coated Balloon in the Treatment of Femoropopliteal Occlusive Disease. J Endovasc Ther. 2016;23(3):409-416. doi:10.1177/1526602816644592
  11. Krankenberg H, Tübler T, Ingwersen M, et al. Drug-Coated Balloon Versus Standard Balloon for Superficial Femoral Artery In-Stent Restenosis: The Randomized Femoral Artery In-Stent Restenosis (FAIR) Trial. Circulation. 2015;132(23):2230-2236. doi:10.1161/CIRCULATIONAHA.115.017364
  12. Baumann F, Fust J, Engelberger RP, et al. Early recoil after balloon angioplasty of tibial artery obstructions in patients with critical limb ischemia. J Endovasc Ther. 2014;21(1):44-51. doi:10.1583/13-4486MR.1
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People say they are Vascular Surgeons, Interventional Radiologists or Angiologists. But for us they are Life Openers.