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Avitene™ Microfibrillar Collagen Hemostat

Microfibrillar Collagen Hemostat Flour

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Standardize on the proven solution for active hemostasis.

Avitene™ Microfibrillar Collagen Hemostat is an active absorbable collagen hemostat, proven to accelerate clot formation. Avitene™ effectively enhances platelet aggregation and the release of proteins to form fibrin, resulting in hemostasis.

Features and Benefits
  • Preloaded sheets for endoscopic delivery in both 5 mm and 10 mm sizes
  • Unlike cautery, avoids thermal damage to primary tissue and adjacent structures
  • Effective in controlling arterial bleeding 
  • Conforms and adheres to irregular spaces 
  • Easy removal with irrigation and suction
  • Cut to any shape or size 
  • Ideal for flat surfaces or to wrap vessels and anastomosis sites


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  • Preloaded 1 gram SyringeAvitene™ Collagen Flour for use in trauma, oncology, general, and cardiovascular surgery


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  • The proven solution for controlling bleeding in all surgical applications, including neurosurgery
  • Trusted by surgeons for its safety and efficacy for over 40 years
  • Easy, effective solution for hemostasis 
  • In an animal study, UltraFoam™ Collagen without thrombin was as effective as Gelfoam® Sponge with thrombin 
  • Reduced thrombin usage may lower cost 
  • Soft, pliable sponge is ready-to-use out of the package 
  • No soaking necessary

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The Basics of Avitene™ Microfibrillar Collagen Hemostat

Avitene™ Microfibrillar Collagen Hemostat is an active absorbable collagen hemostat, proven to accelerate clot formation. It effectively enhances platelet aggregation and the release of proteins to form fibrin, resulting in hemostasis.1

Every product in the Avitene™ MCH family of hemostats is made from 100% collagen,  which is proven to accelerate clot formation across surgical specialties.1 Avitene™ also contains no thrombin and is ready to use right out of the package.1

  • Avitene™ Flour: Avitene™ Flour conforms and adheres to irregular spaces, while controlling arterial bleeding.1
  • Avitene™ Sheets: Avitene™ Sheets can be cut to any size and are ideal for flat surfaces or to wrap vessels and anastomosis sites.1
  • Avitene™  Ultrafoam™ Collagen Sponge: This Soft, pliable sponge is ready-to-use out of the package with no soaking necessary. 2
  • EndoAvitene™ Collagen Hemostat: EndoAvitene™ Applicators are preloaded sheets for endoscopic delivery in both 5 mm and 10 mm sizes.1

Where Can Avitene™ Be Used

Collagen is the most abundant protein in the human body. It has a long history of safe and effective use as a biomaterial in medical technology and offers a series of advantages over synthetic biomaterials. Avitene MCH is an active collagen hemostat, whose collagen is 100% bovine and demonstrates an excellent safety profile trusted by surgeons for over 40 years.3

Avitene™ MCH is acceptable for use in all procedures where a topical hemostat is indicated. Its five versatile form factors provide an effective and simple solution for hemostasis.1

Avitene Sheets are composed of non-woven Avitene collagen fibrils in a sheet form which may be cut into any shape or size, and is highly versatile. Avitene Sheets are commonly used in intracranial and skull base surgery, e.g. tumor removal and neurovascular surgery.1

Avitene MCH is soft, fluffy, moldable form of microfibrillar collagen which is effective in controlling arterial hemorrhage. It conforms and adheres to irregular spaces and it’s easy to remove with gentle irrigation.1

Avitene™ MCH adheres tightly to bloody surfaces and begins working on contact. Collagen in Avitene™ MCH activates platelets, which bind strongly and specifically aggregate and proteins release to form fibrin.1"

 Avitene™ Results, Case Studies, and Risks

Please review the Avitene Publication Summary to learn more.

Please see IFU for full products details relating to risks or complications. 

  1. Avitene™ MCH Instructions for Use
  2. Avitene™ Ultrafoam™ Instructions for Use
  3. Corral M, Ferko N,Hollmann S, et al. Health and economic outcomes associated with uncontrolled surgical bleeding: a retrospective analysis of the Premier Perspectives Database. Clinicoecon Outcomes Res 7, 409-421 (2015)

Animal data may not correlate to outcomes in humans. Data on file.


Avitene™ Microfibrillar Collagen Hemostat (MCH) and Avitene™ UltraFoam™ sponge are indicated in surgical procedures as an adjunct to hemostasis when control of bleeding by ligature or conventional procedures is ineffective or impractical.


  • Avitene™ MCH and Avitene™ UltraFoam™ sponge should not be used in the closure of skin incisions as they may interfere with the healing of the skin edges. This is due to simple mechanical interposition of dry collagen and not to any intrinsic interference with wound healing.
  • It has been reported with other collagen hemostatic agents, that by filling porosities of cancellous bone, they may significantly reduce the bond strength of methylmethacrylate adhesives. Avitene™ MCH and Avitene™ UltraFoam™ sponge should not, therefore, be employed on bone surfaces to which prosthetic materials are to be attached with methylmethacrylate adhesives.


  • Avitene™ MCH and Avitene™ UltraFoam™ are inactivated by autoclaving. Ethylene oxide reacts with bound hydrochloric acid to form ethylene chlorohydrin. These devices have been designed for single use only. Reuse, reprocessing, resterilization or repackaging may compromise the structural integrity and/or essential material and design characteristics that are critical to the overall performance of the devices and may lead to device failure which may result in injury to the patient. Reuse, reprocessing, resterilization or repackaging may also create a risk of contamination of the device and/or cause patient infection or cross infection, including, but not limited to, the transmission of infectious diseases from one patient to another. Contamination of the devices may lead to injury, illness or death of the patient or end user. Opened, unused product should be discarded. Moistening Avitene™ MCH or wetting with saline or thrombin impairs its hemostatic efficacy. It should be used dry.
  • As with any foreign substance, use of Avitene™ MCH and Avitene™ UltraFoam™ in contaminated wounds may enhance infection.
  • Avitene™ UltraFoam™ sponge should not be used in instances of pumping arterial hemorrhage.
  • Avitene™ UltraFoam™ should not be used where blood or other fluids have pooled, or in cases where the point of hemorrhage is submerged as it may mask an underlying source of bleeding, resulting in hematoma.
  • Avitene™ UltraFoam™ sponge will not act as a tampon or plug in a bleeding site, nor will it close off an area of blood collecting behind a tampon.
  • Avitene™ UltraFoam™ sponge is not intended to treat systemic coagulation disorders. Avitene™ MCH and Avitene™ UltraFoam™ are not for injection, intraocular or intravascular use.

Adverse Reactions

  • The most serious adverse reaction reported which may be related to the use of Avitene™ MCH or other collagen products are potentiation of infection including abscess formation, hematoma, wound dehiscence and mediastinitis.
  • Other reported adverse reactions possibly related are adhesion formation, allergic reaction, foreign body reaction and subgaleal seroma (report of a single case) and increased incidence of alveolalgia when used for packing of dental extraction sockets.
  • Transient laryngospasm due to aspiration of dry material has been reported following use of Avitene™ MCH in tonsillectomy.

Please consult package insert for more detailed safety information and instructions for use.