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Progel Platinum™ Surgical Sealant 

A unique option designed to address postoperative air leak complications. 

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Progel™ Pleural Air Leak Sealant

Clinically proven to seal air leaks and reduce the length of stay by an average of 2.1 days.8
Progel Platinum™ Surgical Sealant is a specialised sealant designed with a unique combination of strength, flexibility and adherence, clinically proven to seal leaks and reduce length of hospital stay by 2.1 days.8

Features and Benefits


PEG: strength and flexibility

The proprietary polyethylene glycol (PEG) used in the Progel PlatunumTM formulation is a non-toxic, non immunogenic molecule9 which lends the hydrogel its ability to stretch.

rHA: optimal contact and adherence

Recombinant human albumin (rHA) is a large protein molecule that provides Progel PlatunumTM with its adhesive strength.


    • The only sealant specially designed for the lung and its unique characteristics
    • Combines Polyethylene Glycol (PEG) and Recombinant human albumin (rHA) to form a flexible hydrogel
    • Gels at the tissue site, binding directly to the lung for optimal adherence and an airtight seal
    • Strong enough to withstand re-expansion of the lung within 2 minutes of application1
    • Highly elastic to allow the lung to expand and contract naturally during respiration
    • The patented Progel Platinum™ Extended Tip allows for customized application from a single, easy-to-use device


      • Progel Platinum™ Surgical Sealant is the only sealant approved specifically to seal pleural air leaks in Europe.
      • Progel Platinum™ forms a highly-flexible hydrogel specifically designed for use on the lung.
      • Progel™ Pleural Surgical Sealant (PALS) is the only product FDA approved to treat air leaks regardless of your approach. 2

      Clinically Proven

          • The only sealant clinically proven to effectively treat air leak complications in both open and minimally invasive thoracic surgery1
          • Clinically proven to seal leaks and reduce length of hospital stay by 2.1 days in a prospective, randomized, multi-center trial.8

          Cost Effective

              • As many as 58% of lung surgery patients will have an air leak in the OR3
              • Air leaks are the most important determinant of hospital length of stay (LOS), and a prolonged air leak can extend length of stay by more than 4 days.5
              • The total cost of treating prolonged postoperative air leaks and their associated clinical complications is substantial.6
              • The total 90-day postoperative cost of a prolonged air leak is estimated to be an additional 5000€ per patient.7
              • Progel Platinum™ Surgical Sealant has been shown to effectively seal air leaks during lung surgery, reducing length of hospitalization by 2.1 mean days, potentially minimising associated complications and cost-of-care.8

              Related Videos

              Progel Platinum™ MOA animation

              Progel Platinum™ Surgical Sealant



              Please note, not all products, services or features of products and services may be available in your local area. Please check with your local BD representative


              1. Progel Platinum Surgical Sealant Instructions for Use. Data on file.

              2. Progel Pleural Surgical Sealant (PALS) is not available in EU, its only difference with Progel Platinum™ is that the latter is comprised of a proprietary combination of Recombinant human albumin (rHA) while PALS has human serum albumin (HSA) as the main component.

              3. Allen, Mark S. et al, “Prospective Randomized Study Evaluating a Biodegradable Polymeric Sealant for Sealing Intraoperative Air Leaks That Occur During Pulmonary Resection” Annals of Thoracic Surgery 2004; 77:1792-1801. Pivotal study. Data on file.

              4. Brunelli et al. Predictors of prolonged air leak after pulmonary lobectomy. Ann Thorac Surg 2004; 77: 1205-1210. Based on the reported incidence of prolonged postoperative air leak. Data on file.

              5. Mueller MR, Marzluf BA. The anticipation and management of air leaks and residual spaces post lung resection. J Thorac Dis. 2014 Mar;6(3):271-84. Data on file.

              6. Varela G. et al. Estimating hospital costs attributable to prolonged air leak in pulmonary lobectomy. Eur J Cardiothorac Surg. 2005 Feb;27(2):329-33.

              7. Brunelli A et al. Ninety-day hospital costs associated with prolonged air leak following lung resection. Interact Cardiovasc Thorac Surg. 2020 Oct 1;31(4):507-512.

              8. Zaraca F. et al. Cost-effectiveness analysis of sealant impact in management of moderate intraoperative alveolar air leaks during video-assisted thoracoscopic surgery lobectomy: a multicentre randomised controlled trial. J Thorac Dis. 2017 Dec;9(12):5230-5238)

              9. Davol, Inc. Comprehensive Biocompatibility Study. Data on file.


              • Not all products, services, claims or features of products may be available or valid in your local area. Please check with your local BD representative.

              • Please consult product labels and instructions for use for indications, contradictions, hazards, warnings, and precautions.

              BD-54055 (02/22)