Some power injectable PICCs are open ended like PowerPICC™ Catheters.3 They can be closed with a clamp.4 PowerPICC SOLO™ Catheters don’t have clamps but contain a proximal valve in the hub.1 Positive pressure opens the valve, allowing for infusion.1 Negative pressure opens the valve in the opposite direction, allowing for blood collection.1 The valve closes when pressure is low.5 Low pressure helps prevent backflow and occlusion.5