If you had a tape-secured PIV, then you would have to remove the tape to change the tubing.
StatLock IV Ultra stabilization device
With the StatLock IV Ultra stabilization device you can keep the stabilization device in place while you change tubing. Simply steady the retainer with the thumb and index finger of one hand while unscrewing the extension set. Remove the set. Then, while continuing to brace the retainer, press-fit and screw in your replacement extension set.
StatLock IV Select stabilization device
For StatLock IV Select stabilization device, you will need to replace the StatLock stabilization devices when you remove and replace the tubing – just as you would with tape securement; but this is a rare event offset by StatLock stabilization device advantages.