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Literature

Why PVP-I is the Preferred Choice for Surgical Wound Irrigation

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Surgery Blog Post

Povidone-iodine (PVP-I) has been used in surgical wound irrigation for decades and continues to be supported by leading clinical guidelines. Its broad-spectrum antimicrobial properties and established clinical history make it a trusted choice in intraoperative care.

As the OR evolves, the focus shifts to how PVP-I can be delivered in ways that better support today’s workflows.

Why BD® Surgiphor™ is the optimal choice for PVP-I irrigation

The Surgiphor™ Antimicrobial Irrigation System is a sterile povidone-iodine (PVP-I) solution cleared by the FDA for surgical wound irrigation. Here’s why it stands out:

• Broad-Spectrum Antimicrobial Activity
In vitro antimicrobial efficacy of the preservative in the Surgiphor™ Irrigation System showed: Broad-spectrum activity against common nosocomial bacteria and fungi microorganisms at all time points. Greater than 99.9999% reduction in methicillin-resistant Staphylococcus aureus and E. coli (>6 log10 ) after a 15-second contact time.1,*,+

• Terminal Sterility for Maximum Safety
Surgiphor™ meets a Sterility Assurance Level (SAL) of 10⁻⁶,the same standard required for injectable and implantable products.1,2

• Streamlined Workflow
No dwell time required before suction removal simplifying intraoperative use and saving valuable time in the OR.

• Alignment with Leading Guidelines
Major healthcare organizations, including WHO3, CDC4, SHEA5, and AAOS6, support the use of dilute PVP-I for intraoperative wound irrigation.

Advancing Irrigation with Powered Delivery

Powered irrigation systems, such as pulsed lavage, are widely used in surgical procedures. However, not all irrigation solutions compatible with powered delivery offer the benefits of PVP I. PVP I is a trusted antiseptic that clinicians have used for surgical wound irrigation for decades. It provides broad-spectrum antimicrobial activity and has no known antimicrobial resistance.

Surgiphor™ 1000 mL: Designed for Powered Irrigation

Surgiphor™ 1000mL is the only ready-to-use PVP-I irrigation solution compatible with both manual and powered irrigation systems. This larger volume format enables clinicians to harness the benefits of PVP I while meeting the practical demands of pulse irrigation.

Key features of Surgiphor™ 1000mL:

• Designed for powered irrigation: Compatible with many commonly used powered lavage devices, allowing quick integration into current OR practice.

• Versatile interchangeability: Includes a powered-device adapter, Y-connector for simple switching between saline and Surgiphor™ solution, and a twist cap for manual use when desired, eliminating the need for decanting.

• Optimized flow and ergonomics: Integrated venting promotes smooth, unrestricted flow, while a collapsible bottle supports efficient evacuation and handling.

• Terminally sterile PVP I solution: Part of the only surgical irrigation portfolio that provides terminally sterile PVP-I solutions in multiple sizes and delivery formats.

By combining the mechanical advantages of powered irrigation with the preservative properties of dilute PVP-I, Surgiphor™ 1000 mL enables a more integrated, procedure ready approach to wound irrigation.

Learn how Surgiphor™ 1000 mL and the Surgiphor™ Antimicrobial Irrigation System can support both manual and powered irrigation workflows

Surgiphor™ Antimicrobial Irrigation System
Product description. Surgiphor™ Antimicrobial Irrigation System is an antimicrobial irrigation system containing 0.5% povidone iodine (PVP-I) in phosphate-buffered saline, potassium iodide and Vitamin E TPGS. PVP-I acts as a preservative to help inhibit microbial growth in the irrigation solution. Indication for use. Surgiphor™ Antimicrobial Irrigation System is intended to mechanically loosen and remove debris, and foreign materials, including microorganisms, from wounds. Contraindications. Surgiphor™ Antimicrobial Irrigation System should not be used in patients with known allergic reaction to any of the ingredients in the solutions. Surgiphor™ Antimicrobial Irrigation System should also not be combined with other irrigation or antiseptic solutions due to potential reactions and reduction in the effectiveness of the system. Not for use in neonates. Warnings. Do not use or mix with other cleansers, soaps, lotions, or ointments. Do not use for injection or infusion. Do not swallow. Do not use in eyes or ear canals. Discontinue use immediately if irritation or an allergic reaction occurs. Do not use if packaging is damaged or if seal integrity is compromised. Do not reuse Surgiphor™ solution after 24 hours. Precautions. Surgiphor™ solution may cause a temporary irritation and/or burning sensation on exposed skin in very rare cases. Surgiphor™ solution may cause allergic reactions such as rash or skin irritation in patients with iodine allergy. Anaphylaxis with the use of Surgiphor™ solution may occur in patients with severe iodine allergy. Federal law restricts this device to sale by or on the order of a licensed physician. Single patient use only. Not for at-home use.

Please consult product insert for complete indications, contraindications, warnings, precautions, safety information and instructions for use.

References

* (ATCC #33591) Product should be used only within 24 hours of opening per IFU.

+ PVP-I is an antimicrobial preservative contained within the bottled solution. The Surgiphor™ Irrigation System is not indicated for use as an antimicrobial at or within the wound site.

  1. BD data on file. Data generated in a preclinical model. Data may not correlate to performance in humans.
  2. Sterilization of health care products—Requirements and guidance for selecting a sterility assurance level (SAL) for products labeled “sterile”. ANSI/AAMI ST67:2019. Arlington, VA: Association for the Advancement of Medical Instrumentation; 2019.
  3. World Health Organization. 2018 Global guidelines for the prevention of surgical site infection. Accessed September, 2022, at https://apps.who.int/iris/handle/10665/277399
  4. Berríos-Torres SI, Umscheid CA, Bratzler DW, et al. Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017 [published correction appears in JAMA Surg. 2017;152(8):803]. JAMA Surg. 2017;152(8):784-791. doi:10.1001/jamasurg.2017.0904.
  5. Calderwood MS, Anderson DJ, Bratzler DW, et al. Strategies to prevent surgical site infections in acute-care hospitals: 2022 Update. Infect Control Hosp Epidemiol. 2023;44(5):695-720. doi:10.1017/ice.2023.67.
  6. American Academy of Orthopaedic Surgeons (AAOS). Intraoperative risk factors. In: Surgical Risk Reduction Toolkit. Accessed September 6, 2022, at https://www.aaos.org/quality/quality-programs/quality-toolkits/intraoperative-irrigation/.

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